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Anhedonia  Long-term As of [update] , the long-term effects of MDMA on human brain structure and function have not been fully determined. It is therefore likely that no serotonergic neurotoxicity is present in most casual users. In some cases depressive symptoms persist for longer. Ecstasy was ranked 16th in dependence, physical harm, and social harm. Motor delays may be temporary during infancy or long-term.