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Sperm raises fertility hopes cells nayernia research

Email The face of infertility -- in literature, in the media, in advocacy groups -- is so predominantly female that many often forget about the other part of the equation. But more than a third of infertility cases, which affect 7. Now, new research may provide a glimmer of hope that infertile men may one day be able to contribute to the gene pool. Karim Nayernia, a professor of stem cell biology at Newcastle University in the United Kingdom and the lead researcher on this study, published July 8 in the journal Stem Cells and Development. Skeptics are unconvinced that the researchers have gone as far as creating viable sperm -- sperm that could someday stand in for a male.
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Sperm from Stem Cells to Increase Hopes for Fertility

Share via Email Scientists have paved the way for infertility treatments based on artificial sperm, following the first live births from sperm created in the laboratory. Researchers in Newcastle grew the sperm from mouse embryonic stem cells and used them to fertilise eggs, resulting in the birth of seven mice, according to a study published today. The work readies the ground for tentative attempts to grow fully functioning human sperm from scratch, a technique that - if proved safe - has the potential to help treat male infertility. The research is expected to have greater impact, in the near term at least, by giving scientists the ability to follow the processes by which sperm develop, a powerful tool that could shed light on the root causes of some of the most poorly understood male infertility-related conditions.
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First sperm from stem cells raises fertility hope

Researchers in Newcastle grew the sperm from mouse embryonic stem cells and used them to fertilise eggs, resulting in the birth of seven mice, according to a study published today. The work readies the ground for tentative attempts to grow fully functioning human sperm from scratch, a technique that - if proved safe - has the potential to help treat male infertility. The research is expected to have greater impact, in the near term at least, by giving scientists the ability to follow the processes by which sperm develop, a powerful tool that could shed light on the root causes of some of the most poorly understood male infertility-related conditions. Other scientists have succeeded in generating sperm and even eggs from stem cells, but Professor Nayernia's group is the first to achieve live births. Experts praised the research, but warned that serious abnormalities in all of the mice proved the technique was currently far too risky to consider using to produce human babies.
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They used it to fertilize rat eggs and obtained live births from mice in the laboratory. Rat embryonic stem cells were modified and turned into artificial sperm which was then used to fertilize eggs and led to the births of seven little mice. This gives high hopes for treating infertility in men, as the scientists want to develop human sperm that has exactly the same features as natural sperm in men, but this one will be obtained from scratch.
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